As you are sure to already know, vitiligo is an autoimmune disease, not just a skin condition. The disease is complex in nature with three disease stages: initiation, progression and maintenance. These disease stages are driven by three specific pathophysiological mechanisms: innate immune response activation, T-cell driven inflammatory response & melanocyte destruction, and autoimmune destruction of melanocytes.^1-7

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Howell MD, Kuo FI, et al. Targeting the Janus Kinase Family in Autoimmune Skin Diseases. Front Immunol. 2019;10:2342.
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Chen X, Guo W, et al. Oxidative Stress-Induced IL-15 Trans-Presentation in Keratinocytes Contributes to CD8+ T Cells Activation Via JAK-STAT Pathway in Vitiligo. Free Radic Biol Med. 2019;139:80-91.

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